Durability of BNT162b2 vaccine against hospital and emergency department admissions due to the omicron and delta variants in a large health system in the USA: a test-negative case–control study

Introduction

The SARS-CoV-2 omicron (B.1.1.529) variant was initially recognized in Botswana and South Africa in November, 2021. Compared to the unique SARS-CoV-2 pressure (Wuhan-Hu-1), omicron (together with BA lineages of B.1.1.529) has greater than 30 mutations in its spike (S) protein. Many of these mutations are in the receptor-binding area and have been proven to correspond with a excessive diploma of transmissibility and neutralising antibody escape.

  • Viana R
  • Moyo S
  • Amoako DG
  • et al.
Rapid epidemic growth of the SARS-CoV-2 Omicron variant in southern Africa.